Authors: Bergenholtz G.
Title: Inflammatory response of the dental pulp to bacterial irritation.
Journal: J Endod
Date: Mar 1981
Citation: 7(3):100-4
Category: Endodontic Biology, Histology and Physiology
Evidence-based Ranking: 5
Purpose/Objectives: A summary of the literature involving the pulpal response to bacteria and the toxins they produce.

Results: Bacterial irritants in the carious process – The literature supports the fact that bacteria and the toxins they produce initiate an inflammatory reaction in the pulp and that dentine tubules provide a route for these irritants to the pulp.

Pulpal effect of the bacterial products – Bacteria found in caries and plaque have the capacity to initiate PMN infiltration and abscess formation.

Mechanisms of pulp tissue damage – Pulpal response to bacteria can result in chemotaxis of cell mediated and humoral immunological cells, complement activation, and vascular changes.

Healing capacity of the pulp – The pulp has excellent healing capacity. Inflammatory response can vary from minor to severe, reparative dentin formation can slow the effect of caries, localized abscesses can heal.

Author’s Conclusion: The response of the pulp to bacterial infection is a multifactorial process with excellent healing capacity.

Validity of Conclusion: Valid, however, some literature on cultures from carious bacteria may not be true due to limited sampling techniques at the time.