- Authors: Smith EL.
- Title: How penicillin works.
- Journal: J Endod
- Date: May 1976
- Citation: 2(5):149-52
- Category: Endodontic Pharmacology
- Evidence-based Ranking: 5
- Purpose/Objectives: To described how penicillin works on a chemical level.
Summary: Penicillins inhibit the cross linking of the murein layer of the cell wall by binding to the enzyme transpeptidase. This results in the bacteria being unable to withstand the osmotic pressure of being inside the body and the bacteria lyse.