Authors: Seidberg BH, Schilder H.
Title: An evaluation of EDTA in endodontics.
Journal: Oral Surg Oral Med Oral Pathol
Date: Apr 1974
Citation: 37(4):609-20
Category: Irrigants and Medicaments
Evidence-based Ranking: 5
Purpose/Objectives: The five objectives of this study were 1) quantitate the dentin loss with a known amount of EDTA; 2) Analyze the amount of calcium removed from dentin by a known amount of EDTA; 3) Show the time it takes for a known amount of dentin to be demineralized by EDTA; 4) Determine the effect of a buffered solution per se upon dentin; and 5) Demonstrate the chemical self-limiting properties of EDTA.

Materials & Methods: Human dentin was pulverized, washed with acetone, dried, and then passed through mesh sieves series 20-60, 60-100, 100-200. Different powder sizes were subjected to different amounts and exposure times of EDTA to determine the chelating properties of EDTA.

Results: Excess amounts of EDTA chelated 73% of inorganic dentin. Rate of reaction is most rapid in the first hour. Equilibrium was approached within 7 hours. EDTA proved to be self limiting. Buffering had a negligible affect.

AuthorÂ’s Conclusion: EDTA is an effective chelating agent and is self limiting.

Validity of Conclusion: Seems valid but no statistical analysis.

ReviewerÂ’s Comments: Well designed study.